Mission of our lab

Chen’s Lab from Guangzhou Women and Children’s Medical Center (National Children’s Medical Center) seeks to decipher the genetic architecture and molecular mechanisms of human complex disorders, with a particular focus on birth defects and rare diseases. By integrating rich clinical phenotypes with next-generation sequencing, single-cell omics, and computational genomics, we identify pathogenic variants, major-effect genes, and critical regulatory factors underlying disease susceptibility and developmental abnormalities. We further investigate how genetic variation and gene–gene interactions reshape cellular states, regulatory networks, and developmental pathways. Ultimately, we aim to bridge genetic discovery and mechanistic insight with clinical translation, enabling phenotype-aware diagnosis, genetic risk assessment, precision intervention, and informed reproductive decision-making for women and children.

For scientific inquiries and collaborations, please email Professor Zhongzhong Chen (zhongzhongchen@gmail.com).

Genetic Architecture

Elucidating the pathogenic variants, major-effect genes, and regulatory mechanisms that underlie birth defects and rare disease susceptibility.

Single-Cell and Multi-Omics

Integrating single-cell and multi-omics data to resolve cellular states, gene regulatory networks, and developmental abnormalities.

Clinical Translation

Connecting genetic discovery with phenotype-aware diagnosis, risk assessment, precision intervention, and reproductive counseling.